Searchable abstracts of presentations at key conferences in endocrinology

ea0086p216 | Metabolism, Obesity and Diabetes | SFEBES2022

Simvastatin regulates Il10 gene expression in male and female murine macrophages

Sheridan Alanah , Wheeler-Jones Caroline , Gage Matthew C.

Statins are among the most widely prescribed medications worldwide, decreasing the risk of cardiovascular diseases by reducing cholesterol levels. However, statins also increase the risk of incident type 2 diabetes (T2D), disproportionately affecting women compared to men. Inflammation has emerged as a central factor underpinning T2D pathology, with macrophages playing a significant role. Statins have been found to influence macrophage inflammatory responses, and this has been...